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Every No. 1 NFL Draft pick since 2000: How did they do?

One is a two-time Super Bowl MVP, a couple were nightmares for quarterbacks and one is among the biggest draft busts of all-time.

The No. 1 overall pick is the most coveted in the NFL Draft and while some players live up to the expectations, many turn out to be mediocre talent or disappear from the league within a few short years.

Here is a look at every No. 1 overall draft pick of the 21st century and how their careers panned out.

2000: Courtney Brown, DE, Penn State - Cleveland Browns

Like many a first-round pick by the Browns, Courtney Brown did not live up to the hype. He had a promising rookie season, playing all 16 games and recording 4.5 sacks. But he never played a full year again as injuries piled up. His career ended with 19 sacks over six seasons.

2001: Michael Vick, QB, Virginia Tech - Atlanta Falcons

The mobile passer changed the quarterback position from the moment he first stepped on the field. He was selected to four Pro Bowls and got the Falcons within a game of the Super Bowl in 2004. Vick did a stint in federal prison for a dogfighting operation and missed two seasons before resurrecting his career in Philadelphia. He finished his career with more than 22,000 yards passing, 6,100 yards rushing and a combined 169 touchdowns in 13 seasons.

2002: David Carr, QB, Fresno State - Houston Texans

He was the first pick of the expansion Texans and his career never took off. Over 10 seasons, he ended up throwing more interceptions than touchdowns. Getting sacked 76 times as a rookie didn't help. Carr ended up a journeyman with a career 74.9 passer rating.

2003: Carson Palmer, QB, USC - Cincinnati Bengals

The Heisman Trophy winner helped lead the Bengals back to the playoffs for the first time in 15 years. But frustrations with the organization led to a threat: Trade me or I retire. He was eventually sent to Oakland before playing this final three seasons in Arizona. He finished with more than 46,000 yards passing and nearly 300 touchdowns.

2004: Eli Manning, QB, Ole Miss - San Diego Chargers

Manning refused to play for the Chargers, so was he was traded to the New York Giants during the draft. It would pay off as he won two Super Bowls, taking the MVP trophy both times. Take that away, though, and his career was solid but not spectacular: His 57,000 passing yards put him in the top 10 all-time, but he had a mediocre 236-234 win-loss record and 244 touchdown passes. He retired after the 2019 season.

Credit: AP
New York Giants quarterback Eli Manning (10) runs on the sideline in the second half of an NFL football game against Philadelphia Eagles on Sunday, Dec. 29, 2019, in East Rutherford, N.J. (AP Photo/Adam Hunger)

RELATED: 10 of the NFL Draft's greatest steals

2005: Alex Smith, QB, Utah - San Francisco 49ers

Smith struggled early in his career, but saw a turnaround when Jim Harbaugh arrived in 2011. However, he was replaced by Colin Kaepernick in 2012 after suffering a concussion. Smith was traded to Kansas City the next year, where he flourished for five seasons before being traded to the Redskins. In November 2018, he suffered a horrific injury that nearly cost him his leg. Smith missed the 2019 season but says he plans to play again.

2006: Mario Williams, DE, North Carolina State - Houston Texans

Williams was a force for most of his 11 seasons in the league, mostly with the Texans and Bills. He recorded double-digit sacks five times and finished his career with a total of 97.5 sacks.

2007: JaMarcus Russell, QB, LSU - Oakland Raiders

One of the biggest draft busts in NFL history. Russell held out during his rookie season and ended up starting only one game that year. He was out of the league after three seasons. Russell finished with 4,083 yards passing, 18 touchdowns and 23 interceptions.

Credit: AP
Oakland Raiders quarterback JaMarcus Russell (2) passes against the Denver Broncos in the second quarter of their NFL football game in Oakland, Calif., Sunday, Dec. 2, 2007. (AP Photo/Paul Sakuma)

RELATED: 10 biggest busts in the NFL Draft

2008: Jake Long, T, Michigan - Miami Dolphins

Long is a four-time Pro Bowl selection, all in his first four seasons. He was also named an All-Pro in 2010. Long was hindered by injuries the final three years of his career, missing 33 games over that span. He retired after the 2016 season.

2009: Matthew Stafford, QB, Georgia - Detroit Lions

Eleven seasons into his career, Stafford has put up more than 41,000 passing yards, 256 touchdowns and 134 interceptions. He's one of only eight quarterbacks in NFL history to throw for 5,000 yards in a season.

Credit: AP
Detroit Lions quarterback Matthew Stafford looks downfield during the first half of an NFL football game against the New York Giants, Sunday, Oct. 27, 2019, in Detroit. (AP Photo/Duane Burleson)

2010: Sam Bradford, QB, Oklahoma - St. Louis Rams

Bradford had a promising rookie season, but injuries continued to hound him. After stints with four teams, he did not play in 2019. Bradford sits with less than 20,000 career yards passing.

2011: Cam Newton, QB, Auburn - Carolina Panthers

The physical specimen was a force early in his career, passing and rushing. He led the Panthers to an NFC Championship and won league MVP honors in 2015. But injuries have taken a toll, causing him to play only two games in 2019. He was released by the Panthers in March. 

Credit: AP
Carolina Panthers quarterback Cam Newton (1) reacts after he rushed for a touchdown in the first half of an NFL football game against the Seattle Seahawks, Sunday, Oct. 18, 2015, in Seattle. (AP Photo/Elaine Thompson)

2012: Andrew Luck, QB, Stanford - Indianapolis Colts

After Peyton Manning left for Denver, Luck was the heir in Indy. When he was on the field, he showed why he was worth the top pick. But injuries bedeviled him. Luck missed half the 2015 season and all of 2017. In a surprise, he announced his retirement following the Colts' third preseason game of 2019.

Credit: AP
FILE - In this Jan. 5, 2019 file photo Indianapolis Colts quarterback Andrew Luck (12) throws against the Houston Texans during the first half of an NFL wild card playoff football game in Houston. The popular pick to win the AFC South all offseason has been Andrew Luck and the Indianapolis Colts. The ever-changing diagnosis for his strained left calf and ankle is dredging up bad memories of 2017 when his recovery from shoulder surgery kept him out all season. (AP Photo/Michael Wyke, File)

2013: Eric Fisher, T, Central Michigan - Kansas City Chiefs

Fisher has started nearly every game of his career, but he missed half the season in 2019 with a core muscle injury. He came back to help the Chiefs to its first Super Bowl title in 50 years.

2014: Jadeveon Clowney, DE, South Carolina - Houston Texans

Injuries led to a slow start for Clowney, missing most of his rookie season. He has played in all 16 games only once in his six seasons. Clowney was traded to the Seahawks in 2019. He has 32 career sacks over six years.

Credit: AP
Seattle Seahawks outside linebacker Jadeveon Clowney (90) runs in an interception for a touchdown during the first half of an NFL football game against the Arizona Cardinals, Sunday, Sept. 29, 2019, in Glendale, Ariz. (AP Photo/Rick Scuteri)

2015: Jameis Winston, QB, Florida State - Tampa Bay Buccaneers

Winston's talent and production are matched by his propensity for mistakes. He is one of only eight quarterbacks in history to throw for 5,000 yards in a season, which he did in 2019. But in doing so, he also was the first to throw for 30 touchdowns and 30 interceptions in one season. Seven of those interceptions were returned for touchdowns, also a record. He'll spend 2020 as backup to Drew Brees in New Orleans.

Credit: AP Photo/Tim Ireland
Tampa Bay Buccaneers quarterback Jameis Winston (3) passes against the Carolina Panthers during the second quarter of an NFL football game, Sunday, Oct. 13, 2019, at Tottenham Hotspur Stadium in London.

2016: Jared Goff, QB, California - Los Angeles Rams

Struggled his rookie year, but saw significant improvement under head coach Sean McVay starting in 2017 and 2018. After an NFC Championship season, Goff had an average season in 2019 with 22 touchdowns and 16 interceptions while completing 63% of his passes.

Credit: AP
FILE - In this Sunday, Feb. 3, 2019 file photo, Los Angeles Rams' Jared Goff drops back to pass against the New England Patriots during the second half of the NFL Super Bowl 53 football game in Atlanta.

2017: Myles Garrett, DE, Texas A&M - Cleveland Browns

One of the most feared pass rushers in the league. He has 30.5 sacks in this first three seasons, and that includes missing 11 games. His 2019 season was cut short after an on-field incident in which he pulled the helmet of Steelers QB Mason Rudolph and Rudolph in the head with it. Garrett was suspended for the remainder of the season.

Credit: AP
Cleveland Browns defensive end Myles Garrett is introduced before an NFL football game against the Los Angeles Rams, Sunday, Sept. 22, 2019, in Cleveland. The Rams won 20-13. (AP Photo/David Dermer)

2018: Baker Mayfield, QB, Oklahoma - Cleveland Browns

After a formidable rookie season with 27 touchdown passes and a quarterback rating of 93.7, there were high expectations in 2019 and hopes of a Browns playoff run. The team struggled and Mayfield finished with 22 touchdowns and 21 interceptions while failing to complete 60% of his passes.

Credit: AP
Cleveland Browns quarterback Baker Mayfield warms up before an NFL football game against the Baltimore Ravens, Sunday, Dec. 22, 2019, in Cleveland. (AP Photo/Ron Schwane)

2019: Kyler Murray, QB, Oklahoma - Arizona Cardinals

Murray is coming off a promising rookie season with 3,700 passing yards and 20 touchdowns while completing 65% of his passes. He also rushed for more than 500 yards and four scores.

Credit: Ross D. Franklin/AP
Arizona Cardinals quarterback Kyler Murray (1) throws against the Pittsburgh Steelers during the first half of a game at State Farm Stadium in Glendale, Arizona on Sunday, December 8, 2019.